He divided his time between Paris and the Belgian coast. When he lived in Ostend (Queen of the Belgian coastal cities), he met James Ensor and they became lifelong friends. He was self-taught and strongly influenced by lastnamed friend. Besides Ensor he also was influenced by the world famous Belgian expresionist Constant Permeke, some Flemisch poëts and the film maker Henri Storck.
With Storck he also founded a Ciné club and even made a film about himself. Inspired by poëtry he made his own poëtic reveries.
With his paintings he wanted to describe modern life through a technique of smoothly painted and strongly outlined violent colours. He painted the first of a series of blue women in 1960 (the Bain Turquoise). His paintings were often soft erotic: woman painted in blue and other exaggerated hues who haunted his pictures like a mythical goddess. (On the Other Side of the Grape-harvest Month (1980; Ghent, priv. col.))
He was the subject of a film by Alain Resnais, "Visite à Félix Labisse" (1947). In 1966 he was elected to the Académie des Beaux-Arts. He died in Neuilly-sur-Seine in 1982.